doi: 10.1016/0378-4274(91)90101-b.
Effects of 2,4-dichlorophenoxyacetic acid on polyamine synthesis in Chinese hamster ovary cells
Affiliations
- PMID: 2017772
- DOI: 10.1016/0378-4274(91)90101-b
Item in Clipboard
Effects of 2,4-dichlorophenoxyacetic acid on polyamine synthesis in Chinese hamster ovary cells
Toxicol Lett.
1991 Apr.
Abstract
It was found that 1 mM 2,4-dichlorophenoxyacetate (2,4-D) inhibited DNA and protein synthesis in Chinese hamster ovary (CHO) cells. When the possible relationship of this phenomenon to the presence of polyamines in the culture medium was investigated, it was found that: (a) the pesticide inhibited ornithine decarboxylase activity; (b) when the concentration of polyamines present in cells treated with the pesticide was determined, the putrescine concentration did not change, and the spermine and spermidine concentration decreased; (c) the addition of spermidine and spermine to CHO cells grown in the presence of 2,4-D normalized DNA and protein synthesis. Putrescine did not have any effect.
Similar articles
-
2,4-Dichlorophenoxyacetic acid effects on polyamine biosynthesis.Toxicology. 1991;68(2):109-19. doi: 10.1016/0300-483x(91)90014-r. Toxicology. 1991. PMID: 1891779
-
Control of ornithine decarboxylase in Chinese hamster ovary cells by polyamines. Translational inhibition of synthesis and acceleration of degradation of the enzyme by putrescine, spermidine, and spermine.J Biol Chem. 1986 Jul 15;261(20):9502-8. J Biol Chem. 1986. PMID: 3722208
-
Altered polyamine metabolism in Chinese hamster cells growing in a defined medium.J Cell Physiol. 1986 Apr;127(1):114-20. doi: 10.1002/jcp.1041270115. J Cell Physiol. 1986. PMID: 3958058
-
1,4-Diaminobutane (putrescine), spermidine, and spermine.Annu Rev Biochem. 1976;45:285-306. doi: 10.1146/annurev.bi.45.070176.001441. Annu Rev Biochem. 1976. PMID: 786151 Review.
-
Metabolism and function of polyamines.Int J Biochem. 1985;17(9):943-8. doi: 10.1016/0020-711x(85)90238-1. Int J Biochem. 1985. PMID: 3905448 Review. No abstract available.
Cited by
-
A comparative study on the effects of a pesticide (cypermethrin) and two metals (copper, lead) to serum biochemistry of Nile tilapia, Oreochromis niloticus.Fish Physiol Biochem. 2011 Sep;37(3):657-66. doi: 10.1007/s10695-011-9466-3. Epub 2011 Jan 13. Fish Physiol Biochem. 2011. PMID: 21229307 Free PMC article.
-
Hepatoprotective and Antioxidant Effects of Nanopiperine against Cypermethrin via Mitigation of Oxidative Stress, Inflammations and Gene Expression Using qRT-PCR.Int J Mol Sci. 2023 Oct 19;24(20):15361. doi: 10.3390/ijms242015361. Int J Mol Sci. 2023. PMID: 37895045 Free PMC article.
-
Hepatoprotective Effect of Curcumin Nano-Lipid Carrier against Cypermethrin Toxicity by Countering the Oxidative, Inflammatory, and Apoptotic Changes in Wistar Rats.Molecules. 2023 Jan 16;28(2):881. doi: 10.3390/molecules28020881. Molecules. 2023. PMID: 36677938 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
