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. 2010 Feb 23:8:4.
doi: 10.1186/1477-3155-8-4.

A potential tocopherol acetate loaded palm oil esters-in-water nanoemulsions for nanocosmeceuticals

Brian Sheng Xian Teo  1 , Mahiran Basri, Mohd Rezuwan Shah Zakaria, Abu Bakar Salleh, Raja Noor Zaliha Raja Abdul Rahman, Mohd Basyaruddin Abdul Rahman
Affiliations

A potential tocopherol acetate loaded palm oil esters-in-water nanoemulsions for nanocosmeceuticals

Brian Sheng Xian Teo et al. J Nanobiotechnology. .

Abstract

Background: Cosmeceuticals are cosmetic-pharmaceutical hybrids intended to enhance health and beauty of the skin. Nanocosmeceuticals use nano-sized system for the delivery of active ingredients to the targeted cells for better penetration. In this work, nanoemulsion from palm oil esters was developed as a delivery system to produce nanocosmeceuticals. The stability of the resulting formulation was tested using various methods. In addition, the effect of components i.e. Vitamin E and Pluronic F-68 on the formulation was also studied.

Results: Both vitamin E and Pluronic F-68 were found to co-emulsify and co-stabilized the formulations. The best formulation was found to be the one having the composition of 10% Palm Oil Esters (POEs), 10% vitamin E, 24% Tween 80, 2.4% Pluronic F-68 and 53.6% deionised water. Those compositions are considered to be the best as a nanocosmeceutical product due to the small particle size (94.21 nm), low occurrence of Ostwald ripening and stable at different storing temperatures (5, 25 and 45 degrees C) for four weeks.

Conclusions: Palm oil esters-in-water nanoemulsions loaded with vitamin E was successfully formulated and has the potential for the use as nanocosmeceuticals.

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Figures

Figure 1
Figure 1
Phase Diagram of the water/T80: PF68 (40:1)/POEs systems at 25°C. T80: Tween 80; PF68: Pluronic F-68; POEs: palm oil esters.
Figure 2
Figure 2
Effect of increasing percentage of vitamin E on the droplet size at 25°C.
Figure 3
Figure 3
Effect of time on the droplet size of formulations with increasing percentage of vitamin E at 25°C.
Figure 4
Figure 4
Effect of time on the cubic radius of formulations with increasing percentage of vitamin E at 25°C: Rate of Ostwald ripening.
Figure 5
Figure 5
The molecular structure of DL-α-tocopherol acetate.
Figure 6
Figure 6
Effect of increasing percentage of Pluronic F-68 on the droplet size at 25°C.
Figure 7
Figure 7
Effect of time on the droplet size of formulations with increasing percentage of Pluronic F-68 at 25°C.
Figure 8
Figure 8
Effect of time on the cubic radius of formulations with increasing percentage of Pluronic F-68 at 25°C: Rate of Ostwald ripening.
Figure 9
Figure 9
Particle size distribution graphs for formulations with increasing percentage of vitamin E at 25°C.
Figure 10
Figure 10
Particle size distribution graphs for formulations with increasing percentage of Pluronic F68 (0-2.4%) at 25°C.
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