Chronic active herpes simplex type 2 encephalitis in an asymptomatic immunocompetent child
- PMID: 20179002
- PMCID: PMC3376078
- DOI: 10.1177/0883073809353449
Chronic active herpes simplex type 2 encephalitis in an asymptomatic immunocompetent child
Erratum in
- J Child Neurol. 2010 Dec;25(12):1599
Abstract
A unique form of chronic, active, granulomatous herpes simplex type 2 encephalitis is described in an asymptomatic, immunocompetent 8-year-old girl who acquired the virus as a neonate. The extensive, bilateral cerebral parenchymal involvement was discovered incidentally. Diagnosis was confirmed by a combination of serial neuroimaging, brain biopsy, and quantitative polymerase chain reaction targeted to DNA sequences in the glycoprotein G gene, allowing differentiation between herpes simplex virus types 1 and 2. The clinical course over a 5-year period, treatment with intermittent intravenous steroids, and daily valacyclovir, diagnostic imaging, and laboratory studies are reviewed in detail. This form of herpes simplex virus type 2 encephalitis hasn't been described previously and is significant because of its prolonged indolent course, absence of neurological findings or suggestive history, and benign behavior in this child, who is now 14 years old. The authors believe this entity can be unsuspected and underdiagnosed in the general pediatric population, especially in those with a prior maternal history of herpes simplex virus type 2 infection.
Conflict of interest statement
The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.
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References
-
- Love S, Koch P, Urbach H, Dawson TP. Chronic granulomatous herpes simplex encephalitis in children. J Neuropathol Exp Neurol. 2004;63:1173–1181. - PubMed
-
- Preiser W, Weber B, Klös G, et al. Unusual course of herpes simplex virus encephalitis after acyclovir therapy. Infection. 1996;24:384–389. - PubMed
-
- Hori T, Suzuki T, Terashima Y, et al. Chronic herpes simplex encephalitis with somnambulism: CT, MR, and SPECT findings. Jpn J Psychiatry Neurol. 1990;44:735–739. - PubMed
-
- Jay V, Blaser S, Hwang P, et al. Pathology of chronic herpes infection associated with seizure disorder: a report of two cases with tissue detection of herpes simplex virus 1 by the polymerase chain reaction. Ped Pathol Lab Med. 1995;15:131–146. - PubMed
-
- Assenbauer B, McEntagart M, King MD, et al. Chronic active destructive herpes simplex encephalitis with recovery of viral DNA 12 years after disease onset. Neuropediatrics. 1998;29:120–123. - PubMed
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