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. 2010 May;30(5):895-9.
doi: 10.1038/jcbfm.2010.27. Epub 2010 Feb 24.

Brain glucose overexposure and lack of acute metabolic flexibility in obesity and type 2 diabetes: a PET-[18F]FDG study in Zucker and ZDF rats

Tiziana Liistro  1 , Letizia Guiducci, Silvia Burchielli, Daniele Panetta, Nicola Belcari, Silvia Pardini, Alberto Del Guerra, Piero A Salvadori, Patricia Iozzo
Affiliations

Brain glucose overexposure and lack of acute metabolic flexibility in obesity and type 2 diabetes: a PET-[18F]FDG study in Zucker and ZDF rats

Tiziana Liistro et al. J Cereb Blood Flow Metab. 2010 May.

Abstract

Brain glucose exposure may complicate diabetes and obesity. We used positron emission tomography with (18)F-fluorodeoxyglucose in Zucker obese, diabetic, and control rats to determine the contributions of blood glucose mass action versus local mechanisms in regulating central glucose disposal in fasted and acutely glucose-stimulated states, and their adaptations in obesity and diabetes. Our study data indicate that brain glucose uptake is dependent on both local and mass action components, and is stimulated by acute glucose intake in healthy rats. In diseased animals, the organ was chronically overexposed to glucose, due to high fasting glucose uptake, almost abolishing the physiologic response to glucose loading.

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Figures

Figure 1
Figure 1
(A) Design of a positron emission tomography (PET) study session. (B) Areas under the blood tracer concentration curve (input function) after correcting for individually measured or averaged spillover fractions in 20 animals undergoing frequent blood sampling, showing no difference (left) and a tight correlation (right) between the two methods.
See this image and copyright information in PMC

References

    1. Aragno M, Mastrocola R, Medana C, Restivo F, Catalano MG, Pons N, Danni O, Boccuzzi G. Up-regulation of advanced glycated products receptors in the brain of diabetic rats is prevented by antioxidant treatment. Endocrinology. 2005;146:5561–5567. - PubMed
    1. Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature. 2001;414:813–820. - PubMed
    1. Choi TB, Boado RJ, Pardridge WM. Blood–brain barrier glucose transporter mRNA is increased in experimental diabetes mellitus. Biochem Biophys Res Commun. 1989;164:375–380. - PubMed
    1. Duckrow RB. Glucose transfer into rat brain during acute and chronic hyperglycemia. Metab Brain Dis. 1988;3:201–209. - PubMed
    1. Duckrow RB, Beard DC, Brennan RW. Regional cerebral blood flow decreases during chronic and acute hyperglycemia. Stroke. 1987;18:52–58. - PubMed

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