Continuous separation of cells and particles in microfluidic systems
- PMID: 20179832
- DOI: 10.1039/b915999c
Continuous separation of cells and particles in microfluidic systems
Abstract
The progress in microfabrication and lab-on-a-chip technologies has been a major area of development for new approaches to bioanalytics and integrated concepts for cell biology. Fundamental advances in the development of elastomer based microfluidics have been driving factors for making microfluidic technology available to a larger scientific community in the past years. In line with this, microfluidic separation of cells and particles is currently developing rapidly where key areas of interest are found in designing lab-on-a-chip systems that offer controlled microenvironments for studies of fundamental cell biology. More recently industrial interests are seen in the development of micro chip based flow cytometry technology both for preclinical research and clinical diagnostics. This critical review outlines the most recent developments in microfluidic technology for cell and particle separation in continuous flow based systems. (130 references).
Similar articles
-
Review of cell and particle trapping in microfluidic systems.Anal Chim Acta. 2009 Sep 7;649(2):141-57. doi: 10.1016/j.aca.2009.07.017. Epub 2009 Jul 14. Anal Chim Acta. 2009. PMID: 19699390 Review.
-
Adhesion based detection, sorting and enrichment of cells in microfluidic Lab-on-Chip devices.Lab Chip. 2010 Nov 21;10(22):3043-53. doi: 10.1039/c0lc00130a. Epub 2010 Sep 29. Lab Chip. 2010. PMID: 20877893 Review.
-
Microfluidic sorting system based on optical waveguide integration and diode laser bar trapping.Lab Chip. 2006 Mar;6(3):422-6. doi: 10.1039/b512576f. Epub 2006 Jan 20. Lab Chip. 2006. PMID: 16511626
-
Numerical and experimental evaluation of microfluidic sorting devices.Biotechnol Prog. 2008 Jul-Aug;24(4):981-91. doi: 10.1002/btpr.7. Biotechnol Prog. 2008. PMID: 19194907
-
Cell cytometry with a light touch: sorting microscopic matter with an optical lattice.J Biol Regul Homeost Agents. 2004 Apr-Jun;18(2):200-5. J Biol Regul Homeost Agents. 2004. PMID: 15471228
Cited by
-
On-chip manipulation of single microparticles, cells, and organisms using surface acoustic waves.Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11105-9. doi: 10.1073/pnas.1209288109. Epub 2012 Jun 25. Proc Natl Acad Sci U S A. 2012. PMID: 22733731 Free PMC article.
-
High throughput protein nanocrystal fractionation in a microfluidic sorter.Anal Chem. 2015 Apr 21;87(8):4159-67. doi: 10.1021/acs.analchem.5b00589. Epub 2015 Apr 7. Anal Chem. 2015. PMID: 25794348 Free PMC article.
-
Flexible Microfluidics: Fundamentals, Recent Developments, and Applications.Micromachines (Basel). 2019 Nov 29;10(12):830. doi: 10.3390/mi10120830. Micromachines (Basel). 2019. PMID: 31795397 Free PMC article. Review.
-
Evaluation of multidrug efflux pump inhibitors by a new method using microfluidic channels.PLoS One. 2011 Apr 12;6(4):e18547. doi: 10.1371/journal.pone.0018547. PLoS One. 2011. PMID: 21533264 Free PMC article.
-
Micro- and nanoscale devices for the investigation of epigenetics and chromatin dynamics.Nat Nanotechnol. 2013 Oct;8(10):709-18. doi: 10.1038/nnano.2013.195. Nat Nanotechnol. 2013. PMID: 24091454 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous