Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2010 Sep;25(9):1597-606.
doi: 10.1007/s00467-010-1452-y. Epub 2010 Feb 24.

Vitamin D insufficiency: implications for the immune system

Femke Baeke  1 , Conny Gysemans, Hannelie Korf, Chantal Mathieu
Affiliations
Review

Vitamin D insufficiency: implications for the immune system

Femke Baeke et al. Pediatr Nephrol. 2010 Sep.

Abstract

Chronic kidney disease (CKD) is characterized by a loss of kidney function and dysregulation of vitamin D metabolism. Well known are the defects in final activation of vitamin D to 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], resulting in renal osteodystrophy. However, in recent years, 1,25(OH)(2)D(3) has been identified as having effects far beyond calcium and bone metabolism. In this review, specific attention is given to the effects of 1,25(OH)(2)D(3) on the immune system and the implications of vitamin D deficiency, a feature of many patients with CKD, on immune function.

PubMed Disclaimer

References

    1. J Immunol. 2001 Nov 1;167(9):4974-80 - PubMed
    1. J Lab Clin Med. 2004 Jan;143(1):14-22 - PubMed
    1. J Autoimmun. 2004 Nov;23(3):233-9 - PubMed
    1. J Immunol. 2005 Jan 1;174(1):270-6 - PubMed
    1. Pediatr Nephrol. 2008 Oct;23(10):1831-6 - PubMed

Publication types

LinkOut - more resources