Bowel preparation affects the amplitude and spatiotemporal organization of colonic propagating sequences
- PMID: 20180824
- DOI: 10.1111/j.1365-2982.2010.01480.x
Bowel preparation affects the amplitude and spatiotemporal organization of colonic propagating sequences
Abstract
Background: Colonic manometry is performed using either colonoscopically assisted catheter placement, after bowel preparation, or nasocolonic intubation of the unprepared bowel. There has been little systematic evaluation of the effects of bowel cleansing upon colonic propagating pressure wave sequences.
Methods: Eight healthy volunteers underwent nasocolonic placement of a water-perfused silicone catheter which recorded pressures at 16 recording sites each spaced 7.5 cm apart in the unprepared colon for 24 h. These measures were compared with those obtained in another eight healthy volunteers in whom the catheter was placed to the caecum at colonoscopy in the prepared colon.
Key results: The colonic motor responses to meals and morning waking, and the normal nocturnal suppression did not differ between the two groups, nor were the overall frequency, regional dependence nor extent of propagating sequences (PS) influenced by bowel preparation. Bowel preparation did result in a significant increase in the frequency of high amplitude PS (22 +/- 7 vs 8 +/- 4 HAPS/24 h; P = 0.003). Additionally, a number of the measures of spatiotemporal organization among consecutive PS (linkage among sequences and predefecatory stereotypical patterning) were significantly altered by bowel preparation.
Conclusions & inferences: The overall frequency of PSs, the colonic responses to physiological stimuli such a meal and morning waking and nocturnal suppression, are not influenced by prior bowel preparation. However, investigators wishing to study HAPS frequency, or the more complex spatiotemporal relationships among consecutive PSs, should control for bowel preparation when making comparisons among study groups.
Similar articles
-
Prolonged multi-point recording of colonic manometry in the unprepared human colon: providing insight into potentially relevant pressure wave parameters.Am J Gastroenterol. 2001 Jun;96(6):1838-48. doi: 10.1111/j.1572-0241.2001.03924.x. Am J Gastroenterol. 2001. PMID: 11419837
-
Spatial and temporal organization of pressure patterns throughout the unprepared colon during spontaneous defecation.Am J Gastroenterol. 2000 Apr;95(4):1027-35. doi: 10.1111/j.1572-0241.2000.01839.x. Am J Gastroenterol. 2000. PMID: 10763955
-
Spatio-temporal analysis reveals aberrant linkage among sequential propagating pressure wave sequences in patients with symptomatically defined obstructed defecation.Neurogastroenterol Motil. 2009 Sep;21(9):945-e75. doi: 10.1111/j.1365-2982.2009.01323.x. Epub 2009 May 15. Neurogastroenterol Motil. 2009. PMID: 19453517
-
Intraluminal pressures during perfusion of the human colon in situ.Gastroenterology. 1976 Mar;70(3):336-40. Gastroenterology. 1976. PMID: 765185 Review.
-
1907-2020: more than one century of colonic mass movements in humans.Am J Physiol Gastrointest Liver Physiol. 2021 Jan 1;320(1):G117-G124. doi: 10.1152/ajpgi.00375.2020. Epub 2020 Nov 11. Am J Physiol Gastrointest Liver Physiol. 2021. PMID: 33174455 Review.
Cited by
-
The effect of luminal content and rate of occlusion on the interpretation of colonic manometry.Neurogastroenterol Motil. 2013 Jan;25(1):e52-9. doi: 10.1111/nmo.12051. Epub 2012 Dec 10. Neurogastroenterol Motil. 2013. PMID: 23228077 Free PMC article.
-
First translational consensus on terminology and definitions of colonic motility in animals and humans studied by manometric and other techniques.Nat Rev Gastroenterol Hepatol. 2019 Sep;16(9):559-579. doi: 10.1038/s41575-019-0167-1. Epub 2019 Jul 11. Nat Rev Gastroenterol Hepatol. 2019. PMID: 31296967 Free PMC article. Review.
-
How to perform and assess colonic manometry and barostat study in chronic constipation.J Neurogastroenterol Motil. 2014 Oct 30;20(4):547-52. doi: 10.5056/jnm14056. Epub 2014 Sep 19. J Neurogastroenterol Motil. 2014. PMID: 25230902 Free PMC article.
-
The physiology of human defecation.Dig Dis Sci. 2012 Jun;57(6):1445-64. doi: 10.1007/s10620-012-2071-1. Epub 2012 Feb 26. Dig Dis Sci. 2012. PMID: 22367113 Review.
-
Bio-impedance method to monitor colon motility response to direct distal colon stimulation in anesthetized pigs.Sci Rep. 2022 Aug 12;12(1):13761. doi: 10.1038/s41598-022-17549-6. Sci Rep. 2022. PMID: 35961998 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources