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. 2010 Jan 22:5:3.
doi: 10.1186/1749-8546-5-3.

Antioxidant effects of ethyl acetate extract of Desmodium gangeticum root on myocardial ischemia reperfusion injury in rat hearts

Gino A Kurian  1 , Srilalitha Suryanarayanan, Archana Raman, Jose Padikkala
Affiliations

Antioxidant effects of ethyl acetate extract of Desmodium gangeticum root on myocardial ischemia reperfusion injury in rat hearts

Gino A Kurian et al. Chin Med. .

Abstract

Background: This study aims to evaluate the antioxidant potential of the ethyl acetate extract of Desmodium gangeticum root for cardioprotection from ischemia reperfusion-induced oxidative stress.

Methods: The in vitro antioxidant potential of the extract was in terms of hydroxyl radical scavenging activity, lipid peroxide scavenging activity, nitric oxide scavenging activity and diphenylpicrylhydrazyl radical scavenging activity. The in vivo antioxidant potential of the extract was assessed in an isolated rat heart model.

Results: Free radicals were scavenged by the extract in a concentration-dependent manner within the range of the given concentrations in all models. Administration of the ethyl acetate extract of Desmodium gangeticum root (100 mg per kg body weight) before global ischemia caused a significant improvement of cardiac function and a decrease in the release of lactate dehydrogenase in coronary effluent, as well as the level of malondialdehyde in myocardial tissues.

Conclusion: The ethyl acetate extract of Desmodium gangeticum root protects the myocardium against ischemia-reperfusion-induced damage in rats. The effects of the extract may be related to the inhibition of lipid peroxidation.

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Figures

Figure 1
Figure 1
Activities of creatine kinase and lactate dehydrogenase in the perfusate of isolated rat hearts. Group 1: normal control; Group 2.1, 2.2, 2.3: ischemic reperfusion control; Group 3.1, 3.2, 3.3: drug pretreated and subjected to ischemic reperfusion. Values are mean ± SD in each group (n = 6).
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References

    1. Hasani-Ranjbar S, Larijani B, Abdollahi M. A systematic review of the potential herbal sources of future drugs effective in oxidant-related diseases. Inflamm Allergy Drug Targets. 2009;8(1):2–10. doi: 10.2174/187152809787582561. - DOI - PubMed
    1. Iannitti T, Palmieri B. Antioxidant therapy effectiveness: an up to date. Eur Rev Med Pharmacol Sci. 2009;13(4):245–278. - PubMed
    1. van Rooyen J, Esterhuyse AJ, Engelbrecht AM, du Toit EF. Health benefits of a natural carotenoid rich oil: a proposed mechanism of protection against ischaemia-reperfusion injury. Asia Pac J Clin Nutr. 2008;17(Suppl 1):316–319. - PubMed
    1. Lefer DJ. Emerging role of nitrite in myocardial protection. Arch Pharm Res. 2009;32(8):1127–1138. doi: 10.1007/s12272-009-1804-y. - DOI - PubMed
    1. Niccoli G, Burzotta F, Galiuto L, Crea F. Myocardial no-reflow in humans. J Am Coll Cardiol. 2009;54(4):281–292. doi: 10.1016/j.jacc.2009.03.054. - DOI - PubMed

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