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Case Reports
. 2010 Mar-Apr;31(2):365-8.
doi: 10.1097/BCR.0b013e3181d0f48b.

High-level human herpesvirus-6 viremia associated with onset of Stevens-Johnson syndrome: report of two cases

Amanda F Peppercorn  1 , Melissa B Miller, David Fitzgerald, David J Weber, Pamela A Groben, Bruce A Cairns
Affiliations
Case Reports

High-level human herpesvirus-6 viremia associated with onset of Stevens-Johnson syndrome: report of two cases

Amanda F Peppercorn et al. J Burn Care Res. 2010 Mar-Apr.

Abstract

The pathogenesis of Stevens-Johnson syndrome (SJS) remains obscure, but it has been associated with various infectious agents, including members of the herpesvirus family. We present the first report of high-level human herpesvirus-6 viremia at the onset of SJS, suggesting a possible new association. This finding supports the need for further investigation into the possible relationship between human herpesvirus-6 and SJS, which may illuminate the pathogenesis of SJS and bring us closer to achieving enhanced prevention and treatment of this rare disease.

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Conflict of interest statement

Conflicts of interest: no conflicts for any of the authors

Figures

Figure
Figure
Vacuolar alteration of the dermal epidermal interface associated with scattered apoptotic keratinocytes is present on the left side of the image with progression to subepidermal cleft formation and full thickness epidermal necrosis on the right side of the image (original magnification × 200).
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