Management of acute exacerbations in multiple sclerosis
- PMID: 20182574
- PMCID: PMC2824954
- DOI: 10.4103/0972-2327.58283
Management of acute exacerbations in multiple sclerosis
Abstract
A key component of multiple sclerosis is the occurrence of episodes of clinical worsening with either new symptoms or an increase in older symptoms over a few days or weeks. These are known as exacerbations of multiple sclerosis. In this review, we summarize the pathophysiology and treatment of exacerbations and describe how they are related to the overall management of this disease.
Keywords: Exacerbation; management; multiple sclerosis; relapse; steroids.
Conflict of interest statement
References
-
- Compston A, Coles A. Multiple sclerosis. Lancet. 2008;37264:1502–17. - PubMed
-
- Lublin FD. The incomplete nature of multiple sclerosis relapse resolution. J Neurol Sci. 2007;256:S14–8. - PubMed
-
- Weinshenker BG, Bass B, Rice GP, Noseworthy J, Carriere W, Baskerville J, et al. The natural history of multiple sclerosis: A geographically based study: 2: Predictive value of the early clinical course. Brain. 1989;112:1419–28. - PubMed
-
- Schumacker GA, Beebe G, Kibler RF, Kurland LT, Kurtzke JF, McDowell F, et al. Problems of experimental trials of therapy in multiple sclerosis: Report by the panel on the evaluation of experimental trials of therapy in multiple sclerosis. Ann N Y Acad Sci. 1965;122:552–68. - PubMed
-
- Wingerchuk DM, Rodriguez M. Premenstrual multiple sclerosis pseudoexacerbations: Role of body temperature and prevention with aspirin. Arch Neurol. 2006;63:1005–8. - PubMed
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