Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Feb;40(2):55-61.
doi: 10.4070/kcj.2010.40.2.55. Epub 2010 Feb 23.

Obesity and preclinical changes of cardiac geometry and function

Joong Kyung Sung  1 , Jang-Young Kim
Affiliations

Obesity and preclinical changes of cardiac geometry and function

Joong Kyung Sung et al. Korean Circ J. 2010 Feb.

Abstract

Overweight and obesity are rapidly increasing in prevalence due to adoption of the westernized life style in Korea. Obesity is strongly associated with the development of cardiovascular risk factors such as diabetes, hypertension, and dyslipidemia. In addition, accumulating evidence suggests that obesity per se has a direct effect on cardiac functional and structural changes that may not be the result of atherosclerosis. In this review, we focus on the view that obesity can influence on the structural and functional changes of the heart, drawing evidence from human and animal studies. We also review influencing factors such as physical, neurohormonal, and metabolic alterations that are associated with changes of the heart in obesity.

Keywords: Diastole; Left ventricular dysfunction; Left ventricular hypertrophy; Obesity.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Summary of possible mechanism of structural and functional changes of the heart in obesity. OSA: obstructive sleep apnea, AGE: advanced glycation end-products, IGF-1: insulin-like growth factor-1, TG: triglyceride, RAS: renin angiotensin system.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Park HS, Park CY, Oh SW, Yoo HJ. Prevalence of obesity and metabolic syndrome in Korean adults. Obes Rev. 2008;9:104–107. - PubMed
    1. Kim HM, Park J, Kim HS, Kim DH, Park SH. Obesity and cardiovascular risk factor in Korean children and adolescents aged 10-18 years from the Korean National Health and Nutrition Examination Survey, 1998 and 2001. Am J Epidemiol. 2006;164:787–793. - PubMed
    1. Hubert HB, Feinleib M, McNamara PM, Castelli WP. Obesity as an independent risk factor for cardiovascular disease: a 26-year follow-up of participants in the Framingham Heart Study. Circulation. 1983;67:968–977. - PubMed
    1. Kenchaiah S, Evans JC, Levy D, et al. Obesity and the risk of heart failure. N Engl J Med. 2002;347:305–313. - PubMed
    1. Barouch LA, Berkowitz DE, Harrison RW, O'Donnell CP, Hare JM. Disruption of leptin signaling contributes to cardiac hypertrophy independently of body weight in mice. Circulation. 2003;108:754–759. - PubMed