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. 2010 Feb;40(2):55-61.
doi: 10.4070/kcj.2010.40.2.55. Epub 2010 Feb 23.

Obesity and preclinical changes of cardiac geometry and function

Joong Kyung Sung  1 , Jang-Young Kim
Affiliations

Obesity and preclinical changes of cardiac geometry and function

Joong Kyung Sung et al. Korean Circ J. 2010 Feb.

Abstract

Overweight and obesity are rapidly increasing in prevalence due to adoption of the westernized life style in Korea. Obesity is strongly associated with the development of cardiovascular risk factors such as diabetes, hypertension, and dyslipidemia. In addition, accumulating evidence suggests that obesity per se has a direct effect on cardiac functional and structural changes that may not be the result of atherosclerosis. In this review, we focus on the view that obesity can influence on the structural and functional changes of the heart, drawing evidence from human and animal studies. We also review influencing factors such as physical, neurohormonal, and metabolic alterations that are associated with changes of the heart in obesity.

Keywords: Diastole; Left ventricular dysfunction; Left ventricular hypertrophy; Obesity.

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Figures

Fig. 1
Fig. 1
Summary of possible mechanism of structural and functional changes of the heart in obesity. OSA: obstructive sleep apnea, AGE: advanced glycation end-products, IGF-1: insulin-like growth factor-1, TG: triglyceride, RAS: renin angiotensin system.
See this image and copyright information in PMC

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