Review
doi: 10.1007/s12015-010-9128-3.
Stem cell competition for niche occupancy: emerging themes and mechanisms
Affiliations
- PMID: 20182822
- DOI: 10.1007/s12015-010-9128-3
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Review
Stem cell competition for niche occupancy: emerging themes and mechanisms
Stem Cell Rev Rep.
2010 Sep.
Abstract
Tissue-specific adult stem cells are responsible for generating a range of various differentiated cells during their life time; these cells are intimately associated with niche for maintenance and function. Recent studies of germline stem cell niches in Drosophila gonad suggest that stem cells within a niche constantly compete with each other for niche occupancy. Competition within a niche occurs between same type of stem cells as well as different types. In both cases, cell adhesion molecules are critical in mediating the competition.
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