Effects of transforming growth factor-beta and activin A on vitamin D3-induced monocytic differentiation of myeloid leukemia cells
- PMID: 2018352
Effects of transforming growth factor-beta and activin A on vitamin D3-induced monocytic differentiation of myeloid leukemia cells
Abstract
We examined the effects of transforming growth factors beta(TGF-beta) alone and in combination with 1 alpha,25-dihydroxyvitamin D3 (VD3) on human leukemic cell lines (HEL/S, HL-60 and K562). TGF-beta 1 alone at higher concentrations induced monocytic differentiation of HEL/S cells. Combinations of TGF-beta 1 and VD3 synergistically inhibited cell proliferation and induced monocytic differentiation of HEL/S and HL-60 cells. TGF-beta 2 (a subtype of TGF-beta) and erythroid differentiation factor (EDF/Activin A, a member of the TGF-beta gene family) also inhibited growth and induced monocytic differentiation of HL-60 cells in synergy with VD3. Thus combinations of VD3 and TGF-beta (TGF-beta 1, -beta 2, or EDF) acted synergistically in inhibiting cell proliferation and inducing monocytic differentiation of human leukemia cells.
Similar articles
-
Transforming growth factor-beta potentiates vitamin D3-induced terminal monocytic differentiation of human leukemic cell lines.J Immunol. 1993 Mar 15;150(6):2418-30. J Immunol. 1993. PMID: 8383719
-
Role of CD14 expression in the differentiation-apoptosis switch in human monocytic leukemia cells treated with 1alpha,25-dihydroxyvitamin D3 or dexamethasone in the presence of transforming growth factor beta1.Cell Growth Differ. 1999 Oct;10(10):705-12. Cell Growth Differ. 1999. PMID: 10547074
-
Inhibition by vitamin D3 of erythroid differentiation of human leukemia line cells induced by transforming growth factor beta or erythroid differentiation factor (activin A).Leuk Res. 1991;15(8):721-6. doi: 10.1016/0145-2126(91)90075-5. Leuk Res. 1991. PMID: 1895752
-
Vitamin D3-driven signals for myeloid cell differentiation--implications for differentiation therapy.Leuk Res. 2010 May;34(5):553-65. doi: 10.1016/j.leukres.2009.09.010. Epub 2009 Oct 6. Leuk Res. 2010. PMID: 19811822 Free PMC article. Review.
-
TGF-beta and calcitriol.Gen Pharmacol. 1998 Feb;30(2):145-51. doi: 10.1016/s0306-3623(97)00271-1. Gen Pharmacol. 1998. PMID: 9502167 Review.
Cited by
-
An anti-cancer derivative of butyric acid (pivalyloxmethyl buterate) and daunorubicin cooperatively prolong survival of mice inoculated with monocytic leukaemia cells.Br J Cancer. 1997;75(6):850-4. doi: 10.1038/bjc.1997.151. Br J Cancer. 1997. PMID: 9062406 Free PMC article.
-
Vitamin D supplementation lowers thrombospondin-1 levels and blood pressure in healthy adults.PLoS One. 2017 May 10;12(5):e0174435. doi: 10.1371/journal.pone.0174435. eCollection 2017. PLoS One. 2017. PMID: 28489857 Free PMC article.
-
Association of activins, follistatins and inhibins with incident hip fracture in women with postmenopausal osteoporosis: a proof of concept, case-control study.Endocrine. 2023 Sep;81(3):573-578. doi: 10.1007/s12020-023-03402-x. Epub 2023 May 23. Endocrine. 2023. PMID: 37221430