Review
doi: 10.1080/15257770903054159.
The unabated synthesis of new nucleoside analogues with antiviral potential: a tribute to Morris J. Robins
Affiliations
- PMID: 20183603
- DOI: 10.1080/15257770903054159
Item in Clipboard
Review
The unabated synthesis of new nucleoside analogues with antiviral potential: a tribute to Morris J. Robins
Nucleosides Nucleotides Nucleic Acids.
2009 May.
Abstract
The furo[2,3-d]pyrimidin-2(3H)-one is the key structural determinant in the exquisitely potent activity of its derivatives (R = 2-deoxyribosyl; R' = p-pentylphenyl) against VZV (varicella-zoster virus) replication. [structure: see text].
Similar articles
-
Rapid synthesis of 2',3'-dideoxy-3'β-fluoro-pyrimidine nucleosides from 2'-deoxypyrimidine nucleosides.Bioorg Chem. 2010 Dec;38(6):271-4. doi: 10.1016/j.bioorg.2010.08.003. Epub 2010 Sep 7. Bioorg Chem. 2010. PMID: 20869741
-
Synthesis and biological evaluation of acyclic 3-[(2-hydroxyethoxy)methyl] analogues of antiviral furo- and pyrrolo[2,3-d]pyrimidine nucleosides.J Med Chem. 2005 Jul 14;48(14):4690-6. doi: 10.1021/jm050291s. J Med Chem. 2005. PMID: 16000005
-
Synthesis and antiviral evaluation of 6-(alkyl-heteroaryl)furo[2,3-d]pyrimidin-2(3H)-one nucleosides and analogues with ethynyl, ethenyl, and ethyl spacers at C6 of the furopyrimidine core.J Med Chem. 2007 Aug 9;50(16):3897-905. doi: 10.1021/jm070210n. Epub 2007 Jul 10. J Med Chem. 2007. PMID: 17622128
-
Highly potent and selective inhibition of varicella-zoster virus replication by bicyclic furo[2,3-d]pyrimidine nucleoside analogues.Med Res Rev. 2003 May;23(3):253-74. doi: 10.1002/med.10035. Med Res Rev. 2003. PMID: 12647310 Review.
-
5-(1-Substituted) alkyl pyrimidine nucleosides as antiviral (herpes) agents.Curr Med Chem. 2004 Oct;11(20):2749-66. doi: 10.2174/0929867043364388. Curr Med Chem. 2004. PMID: 15544474 Review.
Cited by
-
Palladium-catalyzed modification of unprotected nucleosides, nucleotides, and oligonucleotides.Molecules. 2015 May 22;20(5):9419-54. doi: 10.3390/molecules20059419. Molecules. 2015. PMID: 26007192 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources