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. 2009 May;28(5):713-23.
doi: 10.1080/15257770903128870.

Synthesis and antiviral evaluation of 2'-C-methyl analogues of 5-alkynyl- and 6-alkylfurano- and pyrrolo[2,3-d]pyrimidine ribonucleosides

Piotr Januszczyk  1 , Joanna Fogt, Jerzy Boryski, Kunisuke Izawa, Tomoyuki Onishi, Johan Neyts, Erik De Clercq
Affiliations

Synthesis and antiviral evaluation of 2'-C-methyl analogues of 5-alkynyl- and 6-alkylfurano- and pyrrolo[2,3-d]pyrimidine ribonucleosides

Piotr Januszczyk et al. Nucleosides Nucleotides Nucleic Acids. 2009 May.

Abstract

A series of novel 2'-C-methylribonucleosides, involving 5-iodo and 5-alkynyl uridine analogues as well as related bicyclic furano- and pyrrolo[2,3-d]pyrimidinone compounds, has been synthesized and evaluated for their inhibitory effect on replication of the hepatitis C virus (HCV). The new nucleoside analogues did not show meaningful anti-HCV activity.

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