doi: 10.1038/268115a0.
Protein-DNA and protein-hormone interactions in prealbumin: a model of the thyroid hormone nuclear receptor?
- PMID: 201845
- DOI: 10.1038/268115a0
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Protein-DNA and protein-hormone interactions in prealbumin: a model of the thyroid hormone nuclear receptor?
Nature.
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Abstract
High resolution X-ray analysis of the hormone-binding protein prealbumin has shown that it has a structural complementarity to double-helical DNA. The proposed binding site is composed of two symmetry-related beta-sheets containing a pair of helically disposed arms, which can interact with the bases in the wide groove of DNA. A palindromic target sequence is indicated by the symmetry of the protein. The two identical thyroid hormone binding sites on prealbumin are located in a channel that runs completely through the molecule. These two structural features suggest prealbumin as a model for the thyroid hormone nuclear receptor, providing a number of detailed predictions of its properties.
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