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. 1991 Jan;21(1):49-65.
doi: 10.1007/BF01067666.

Simultaneous genetic analysis of longitudinal means and covariance structure in the simplex model using twin data

C V Dolan  1 , P C Molenaar, D I Boomsma
Affiliations
Free article

Simultaneous genetic analysis of longitudinal means and covariance structure in the simplex model using twin data

C V Dolan et al. Behav Genet. 1991 Jan.
Free article

Abstract

A longitudinal model based on the simplex model is presented to analyze simultaneously means and covariance structure using univariate longitudinal twin data. The objective of the model is to decompose the mean trend into components which can be attributed to those genetic and environmental factors which give rise to phenotypic individual differences and a component of unknown constitution which does not involve individual differences. Illustrations are given using simulated data and repeatedly measured weight obtained in a sample of 82 female twin pairs on six occasions.

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