Adenosquamous carcinoma of the ovary arising from endometriosis: two case reports

Abstract

The author reports two cases of adenosquamous carcinoma arising from endometriosis of ovaries. The tumor patients were 38-year-old and 53-year-old women. Both patients underwent hysterectomy and bilateral salpingo-oophorectomy for ovarian carcinomas. Grossly, both ovarian tumors were located in the left ovaries, and were cystic tumors with mural tumors. Histologically, the cystic areas consisted of endometrial glandular epithelium. Both mural tumors were composed of grade I endometroid adenocarcinoma and squamous cell carcinoma. These two elements were admixed in some areas. A differentiation of endometrioid adenocarcinoma from the endometriosis were present in a few areas. Likewise, a differentiation of squamous cell carcinoma from the endometriosis were recognized in several areas. The pathologic diagnosis was adenosquamous carcinoma arising from endometriosis of the ovary in both cases, rather than endometrioid adenocarcinoma with malignant squamous differentiation. No tumors were present in other organs.

Figure 1

Gross features of endometriosis of the ovary containing adenosquamous carcinoma. The tumor is cystic. The thicken wall area is a carcinoma, and thin wall area is endometriosis.

Figure 2

Histopathology of adenosquamous carcinoma of the ovary arising from endometriosis.

Figure 3

Grade I endometrioid adenocarcinoma of grade I is present within the tumor. HE, ×200.

Figure 4

Squamous cell carcinoma is recognized within the tumor. C: A transition between endometorioid adenocarcinoma and endometriosis is present. This suggests that the endometrioid adenocarcinoma is derived from endometriosis. HE, ×200.

Figure 5

A transition between squamous cell carcinoma and endometrosis is recognized. This strongly suggests that the squamous cell carcinoma arise from endometriosis. HE, ×200.