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. 2009 Aug 11:2:8875.
doi: 10.1186/1757-1626-0002-0000008875.

Primary lymphoma of the prostate treated with rituximab-based chemotherapy: a case report and review of the literature

Amina Taleb  1 , Nabil Ismaili, Rhizlane Belbaraka, Abdellah Bensouda, Ibrahim Elghissassi, Omar Elmesbahi, Jean Pierre Droz, Hassan Errihani
Affiliations

Primary lymphoma of the prostate treated with rituximab-based chemotherapy: a case report and review of the literature

Amina Taleb et al. Cases J. .

Abstract

Introduction: Primary lymphoma of the prostate is very rare. In this paper we present a case of early stage non-Hodgkin lymphoma of the prostate managed with six cycles of rituximab-based chemotherapy, and review the related literature.

Case presentation: An 84-year-old man was admitted to our hospital having signs and symptoms suggestive of prostatic disease for 3 years. Histological and immunocytochemical studies of trans-urethral biopsy of the prostate showed diffuse large B-cell lymphoma. Radiological assessment of disease confirmed the diagnosis of early stage lymphoma of the prostate. The patient was managed by 6 of rituximab 375 mg/m2 on day 1, cyclophosphamide 750 mg/m2 on day 1, doxorubicin 50 mg/m2 on day 1, vincristine 1.4 mg/m2 on day 1, and prednisone 50 mg/m2 on days 1 to 5 with complete clinical and radiological response. He remained disease free, until now, 30 months after the end of chemotherapy.

Conclusion: According to the literature, the treatment and prognosis of primary lymphoma of the prostate is the same as that of other nodal lymphomas. Rituximab-based regimen should be considered in the management of prostatic diffuse large B-cell lymphoma.

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Figures

Figure 1
Figure 1
CT scan of the pelvis shows the tumoral process infiltrated the base of the prostate gland.
Figure 2
Figure 2
T2 weighted coronal section fat-suppressed shows the process in the left base of the prostate which invades the bladder base.
Figure 3
Figure 3
T1 weighted coronal section after injection of gadolinium shows abnormal enhancement of the prostate and the bladder base.
Figure 4
Figure 4
CT scan of the pelvis performed after chemotherapy shows complete radiological response of the prostatic tumour.
See this image and copyright information in PMC

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References

    1. Freeman C, Berg JW, Cutler SJ. Occurrence and prognosis of extranodal lymphomas. Cancer. 1972;29:252–260. doi: 10.1002/1097-0142(197201)29:1<252::AID-CNCR2820290138>3.0.CO;2-#. - DOI - PubMed
    1. Patel DR, Gomez GA, Henderson ES, Gamarra M. Primary prostatic involvement in non Hodgkin lymphoma. Urology. 1988;32:96–98. doi: 10.1016/0090-4295(88)90305-6. - DOI - PubMed
    1. Sarris A, Dimopoulos M, Pugh W, Cabanillas F. Primary lymphoma of the prostate: good outcome with doxorubicin-based combination chemotherapy. J Urol. 1995;153:1852–1854. doi: 10.1016/S0022-5347(01)67330-0. - DOI - PubMed
    1. Zein TA, Huben R, Lane W, Pontes JE, Englander LS. Secondary tumors of the prostate. J Urol. 1985;133:615–616. - PubMed
    1. Bostwick DG, Iczkowski KA, Amin MB, Discigil G, Osborne B. Malignant lymphoma involving the prostate: report of 62 cases. Cancer. 1998;83:732–738. doi: 10.1002/(SICI)1097-0142(19980815)83:4<732::AID-CNCR15>3.0.CO;2-T. - DOI - PubMed

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