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. 1991 Mar 15;175(2):532-6.
doi: 10.1016/0006-291x(91)91597-6.

Synergistic effect of magnesium and calcium ions in the activation of phospholipase A2 of liver macrophages

H Krause  1 , P Dieter, A Schulze-Specking, A Ballhorn, E Ferber, K Decker
Affiliations

Synergistic effect of magnesium and calcium ions in the activation of phospholipase A2 of liver macrophages

H Krause et al. Biochem Biophys Res Commun. .

Abstract

In cell-free extracts of rat liver macrophages (Kupffer cells) phospholipase A2 was found to be strongly activated at free Ca2+ concentrations from 100 nM to 1 microM in the presence of 4 mM free Mg2+. This is within the range of intracellular free Ca2+ reported for basal and various stimulated conditions, respectively. Ca2+ alone increased phospholipase A2 activity at high Ca2+ concentrations (1 mM) whereas Mg2+ alone had only little stimulatory effect. Calmodulin does not seem to participate in the regulation of phospholipase A2 although it relieved the inhibition of phospholipase A2 activity by calmodulin antagonists.

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