Comment in

• Counterpoint: Activation of the intrarenal renin-angiotensin system is the dominant contributor to systemic hypertension.

  Navar LG. Navar LG. J Appl Physiol (1985). 2010 Dec;109(6):1998-2000; discussion 2015. doi: 10.1152/japplphysiol.00182.2010a. J Appl Physiol (1985). 2010. PMID: 21148349 Free PMC article. No abstract available.
• Rebuttal from Navar.

  Navar LG. Navar LG. J Appl Physiol (1985). 2010 Dec;109(6):2001-2. doi: 10.1152/japplphysiol.00182.2010c. J Appl Physiol (1985). 2010. PMID: 21148351 No abstract available.
• Comments on Point:Counterpoint: The dominant contributor to systemic hypertension: Chronic activation of the sympathetic nervous system vs. Activation of the intrarenal renin-angiotensin system. Activated intrarenal renin-angiotensin system is correlated with high blood pressure in humans.

  Kobori H, Fu Q, Crowley SD, Gonzalez-Villalobos RA, Campos RR. Kobori H, et al. J Appl Physiol (1985). 2010 Dec;109(6):2003. doi: 10.1152/japplphysiol.01160.2010. J Appl Physiol (1985). 2010. PMID: 21148352 Free PMC article. No abstract available.
• Comments on Point:Counterpoint: The dominant contributor to systemic hypertension: Chronic activation of the sympathetic nervous system vs. Activation of the intrarenal renin-angiotensin system. Systemic hypertension--a "ratologist" point of view.

  Julien C. Julien C. J Appl Physiol (1985). 2010 Dec;109(6):2004. doi: 10.1152/japplphysiol.01160.2010. J Appl Physiol (1985). 2010. PMID: 21188799 No abstract available.
• Comments on Point:Counterpoint: The dominant contributor to systemic hypertension: Chronic activation of the sympathetic nervous system vs. Activation of the intrarenal renin-angiotensin system. Sympathetic activation is the dominant contributor to systemic hypertension.

  Fu Q, Levine BD. Fu Q, et al. J Appl Physiol (1985). 2010 Dec;109(6):2012. doi: 10.1152/japplphysiol.01160.2010. J Appl Physiol (1985). 2010. PMID: 21188802 No abstract available.
• Comments on Point:Counterpoint: The dominant contributor to systemic hypertension: Chronic activation of the sympathetic nervous system vs. Activation of the intrarenal renin-angiotensin system. Sympathetic nervous system, plasma volume, and hypertension.

  Christensen NJ. Christensen NJ. J Appl Physiol (1985). 2010 Dec;109(6):2003. doi: 10.1152/japplphysiol.01160.2010. J Appl Physiol (1985). 2010. PMID: 21188813 No abstract available.
• Comments on Point:Counterpoint: The dominant contributor to systemic hypertension: Chronic activation of the sympathetic nervous system vs. Activation of the intrarenal renin-angiotensin system. Systemic hypertension--involvement of the CNS to this complex puzzle.

  Moreira TS, Takakura AC, Antunes VR. Moreira TS, et al. J Appl Physiol (1985). 2010 Dec;109(6):2004. doi: 10.1152/japplphysiol.01160.2010. J Appl Physiol (1985). 2010. PMID: 21188814 No abstract available.
• Comments on Point:Counterpoint: The dominant contributor to systemic hypertension: Chronic activation of the sympathetic nervous system vs. Activation of the intrarenal renin-angiotensin system. Chronic activation of sympathetic nervous system and systemic hypertension--stress shows the way.

  Fontes MA, Xavier CH. Fontes MA, et al. J Appl Physiol (1985). 2010 Dec;109(6):2004-5. doi: 10.1152/japplphysiol.01160.2010. J Appl Physiol (1985). 2010. PMID: 21188815 No abstract available.
• Comments on Point:Counterpoint: The dominant contributor to systemic hypertension: Chronic activation of the sympathetic nervous system vs. Activation of the intrarenal renin-angiotensin system.

  Goldstein DS. Goldstein DS. J Appl Physiol (1985). 2010 Dec;109(6):2005-6. doi: 10.1152/japplphysiol.01160.2010. J Appl Physiol (1985). 2010. PMID: 21188816 No abstract available.
• Comments on Point:Counterpoint: The dominant contributor to systemic hypertension: Chronic activation of the sympathetic nervous system vs. Activation of the intrarenal renin-angiotensin system. Activation of the sympathetic nervous system is the dominant contributor to systemic hypertension.

  Negrao CE, Negrao MV. Negrao CE, et al. J Appl Physiol (1985). 2010 Dec;109(6):2006. J Appl Physiol (1985). 2010. PMID: 21188817 No abstract available.
• Comments on Point:Counterpoint: The dominant contributor to systemic hypertension: Chronic activation of the sympathetic nervous system vs. Activation of the intrarenal renin-angiotensin system.

  Rohrwasser A. Rohrwasser A. J Appl Physiol (1985). 2010 Dec;109(6):2007. J Appl Physiol (1985). 2010. PMID: 21188818 No abstract available.
• Comments on Point:Counterpoint: The dominant contributor to systemic hypertension: Chronic activation of the sympathetic nervous system vs. Activation of the intrarenal renin-angiotensin system.

  Li P. Li P. J Appl Physiol (1985). 2010 Dec;109(6):2008. doi: 10.1152/japplphysiol.01160.2010. J Appl Physiol (1985). 2010. PMID: 21188819 No abstract available.
• Comments on Point:Counterpoint: The dominant contributor to systemic hypertension: Chronic activation of the sympathetic nervous system vs. Activation of the intrarenal renin-angiotensin system. The kidney is not always the target in neurogenic hypertension.

  Osborn JW, Fink GD. Osborn JW, et al. J Appl Physiol (1985). 2010 Dec;109(6):2008. doi: 10.1152/japplphysiol.01160.2010. J Appl Physiol (1985). 2010. PMID: 21188820 No abstract available.
• Comments on Point:Counterpoint: The dominant contributor to systemic hypertension: Chronic activation of the sympathetic nervous system vs. Activation of the intrarenal renin-angiotensin system. Carotid stimulation studies support a prominent role for the sympathetic nervous system.

  Wehrwein EA. Wehrwein EA. J Appl Physiol (1985). 2010 Dec;109(6):2009. doi: 10.1152/japplphysiol.01160.2010. J Appl Physiol (1985). 2010. PMID: 21188821 No abstract available.
• Comments on Point:Counterpoint: The dominant contributor to systemic hypertension: Chronic activation of the sympathetic nervous system vs. Activation of the intrarenal renin-angiotensin system.

  Cowley AW Jr. Cowley AW Jr. J Appl Physiol (1985). 2010 Dec;109(6):2009-10. doi: 10.1152/japplphysiol.01160.2010. J Appl Physiol (1985). 2010. PMID: 21188824 No abstract available.
• Comments on Point:Counterpoint: The dominant contributor to systemic hypertension: Chronic activation of the sympathetic nervous system vs. Activation of the intrarenal renin-angiotensin system.

  Head GA, Burke SL. Head GA, et al. J Appl Physiol (1985). 2010 Dec;109(6):2010. doi: 10.1152/japplphysiol.01160.2010. J Appl Physiol (1985). 2010. PMID: 21188825 No abstract available.
• Comments on Point:Counterpoint: The dominant contributor to systemic hypertension: Chronic activation of the sympathetic nervous system vs. Activation of the intrarenal renin-angiotensin system. The dominant mechanism depends on individual circumstance.

  Mathai ML. Mathai ML. J Appl Physiol (1985). 2010 Dec;109(6):2011. doi: 10.1152/japplphysiol.01160.2010. J Appl Physiol (1985). 2010. PMID: 21188826 No abstract available.
• Comments on Point:Counterpoint: The dominant contributor to systemic hypertension: Chronic activation of the sympathetic nervous system vs. Activation of the intrarenal renin-angiotensin system. Remodeling of central sympathetic circuits precedes the development of hypertension.

  Murphy MN. Murphy MN. J Appl Physiol (1985). 2010 Dec;109(6):2011-2. doi: 10.1152/japplphysiol.01160.2010. J Appl Physiol (1985). 2010. PMID: 21188827 No abstract available.
• Comments on Point:Counterpoint: The dominant contributor to systemic hypertension: Chronic activation of the sympathetic nervous system vs. Activation of the intrarenal renin-angiotensin system. AT1 receptors in the kidney mediate the chronic hypertensive response to angiotensin II.

  Crowley SD. Crowley SD. J Appl Physiol (1985). 2010 Dec;109(6):2012-3. doi: 10.1152/japplphysiol.01160.2010. J Appl Physiol (1985). 2010. PMID: 21188828 No abstract available.
• Comments on Point:Counterpoint: The dominant contributor to systemic hypertension: Chronic activation of the sympathetic nervous system vs. Activation of the intrarenal renin-angiotensin system. Intrarenal angiotensin II generation as a hypertensinogenic mechanism.

  Gonzalez-Villalobos RA, Fuchs S. Gonzalez-Villalobos RA, et al. J Appl Physiol (1985). 2010 Dec;109(6):2013. doi: 10.1152/japplphysiol.01160.2010. J Appl Physiol (1985). 2010. PMID: 21188829 No abstract available.
• Comments on Point:Counterpoint: The dominant contributor to systemic hypertension: Chronic activation of the sympathetic nervous system vs. Activation of the intrarenal renin-angiotensin system. Sympathetic activation: cause or consequence of hypertension?

  Campos RR, Bergamaschi CT. Campos RR, et al. J Appl Physiol (1985). 2010 Dec;109(6):2013-4. doi: 10.1152/japplphysiol.01160.2010. J Appl Physiol (1985). 2010. PMID: 21188830 No abstract available.
• Comments on Point:Counterpoint: The dominant contributor to systemic hypertension: Chronic activation of the sympathetic nervous system vs. Activation of the intrarenal renin-angiotensin system. The role of the sympathetic nervous system--influences of sex and aging.

  Charkoudian N, Hart EC, Barnes JN, Joyner MJ. Charkoudian N, et al. J Appl Physiol (1985). 2010 Dec;109(6):2005. doi: 10.1152/japplphysiol.01160.2010. J Appl Physiol (1985). 2010. PMID: 21188833 No abstract available.
• Comments on Point:Counterpoint: The dominant contributor to systemic hypertension: Chronic activation of the sympathetic nervous system vs. Activation of the intrarenal renin-angiotensin system.

  Cohn JN. Cohn JN. J Appl Physiol (1985). 2010 Dec;109(6):2006-7. doi: 10.1152/japplphysiol.01160.2010. J Appl Physiol (1985). 2010. PMID: 21188834 No abstract available.
• Comments on Point:Counterpoint: The dominant contributor to systemic hypertension: Chronic activation of the sympathetic nervous system vs. Activation of the intrarenal renin-angiotensin system. Obesity: a common prime mover of chronic activation of the sympathetic nervous system and the renin-angiotensin system in systemic hypertension?

  Szelényi Z. Szelényi Z. J Appl Physiol (1985). 2010 Dec;109(6):2008-9. doi: 10.1152/japplphysiol.01160.2010. J Appl Physiol (1985). 2010. PMID: 21188835 No abstract available.
• Comments on Point:Counterpoint: The dominant contributor to systemic hypertension: Chronic activation of the sympathetic nervous system vs. Activation of the intrarenal renin-angiotensin system.

  Zhao D. Zhao D. J Appl Physiol (1985). 2010 Dec;109(6):2010. doi: 10.1152/japplphysiol.01160.2010. J Appl Physiol (1985). 2010. PMID: 21188837 No abstract available.
• Comments on Point:Counterpoint: The dominant contributor to systemic hypertension: Chronic activation of the sympathetic nervous system vs. Activation of the intrarenal renin-angiotensin system. Dominant contributors for systemic hypertension--who leads, who follows?

  Braga VA. Braga VA. J Appl Physiol (1985). 2010 Dec;109(6):2007-8. doi: 10.1152/japplphysiol.01160.2010. J Appl Physiol (1985). 2010. PMID: 21188840 No abstract available.
• Comments on Point:Counterpoint: The dominant contributor to systemic hypertension: Chronic activation of the sympathetic nervous system vs. Activation of the intrarenal renin-angiotensin system. Hung jury?

  Bie P, Damkjaer M. Bie P, et al. J Appl Physiol (1985). 2010 Dec;109(6):2011. doi: 10.1152/japplphysiol.01160.2010. J Appl Physiol (1985). 2010. PMID: 21188841 No abstract available.