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Comment

. 2010 Feb 26;327(5969):1091-2.

doi: 10.1126/science.1187790.

Biochemistry. What makes a prion infectious?

Surachai Supattapone¹

Affiliations

PMID: 20185716
PMCID: PMC11808538
DOI: 10.1126/science.1187790

Comment

Biochemistry. What makes a prion infectious?

Surachai Supattapone. Science. 2010.

. 2010 Feb 26;327(5969):1091-2.

doi: 10.1126/science.1187790.

Author

Surachai Supattapone¹

Affiliation

¹ Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755, USA. supattapone@dartmouth.edu

PMID: 20185716
PMCID: PMC11808538
DOI: 10.1126/science.1187790

No abstract available

PubMed Disclaimer

Figures

None — Extra ingredients.
Two different biochemical protocols yield recombinant PrP with different infectivity. (Left) Minimally infectious amyloid fibrils are formed by incubating recombinant PrP with chemical denaturants. (Right) Mixing recombinant PrP with phospholipid and RNA produces highly infectious prions.

See this image and copyright information in PMC

Comment on

Generating a prion with bacterially expressed recombinant prion protein.
Wang F, Wang X, Yuan CG, Ma J. Wang F, et al. Science. 2010 Feb 26;327(5969):1132-5. doi: 10.1126/science.1183748. Epub 2010 Jan 28. Science. 2010. PMID: 20110469 Free PMC article.

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References

1. Wong C et al., EMBO J. 20, 377 (2001). - PMC - PubMed
1. Wang F et al., Biochemistry 46, 7045 (2007). - PubMed
1. Deleault NR, HarrEis BT, Rees JR, Supattapone S, Proc. Natl. Acad. Sci. U.S.A. 104, 9741 (2007). - PMC - PubMed
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