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Comment
. 2010 Feb 26;327(5969):1091-2.
doi: 10.1126/science.1187790.

Biochemistry. What makes a prion infectious?

Surachai Supattapone  1
Affiliations
Comment

Biochemistry. What makes a prion infectious?

Surachai Supattapone. Science. .
No abstract available

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Figures

None
Extra ingredients.
Two different biochemical protocols yield recombinant PrP with different infectivity. (Left) Minimally infectious amyloid fibrils are formed by incubating recombinant PrP with chemical denaturants. (Right) Mixing recombinant PrP with phospholipid and RNA produces highly infectious prions.
See this image and copyright information in PMC

Comment on

References

    1. Wong C et al., EMBO J. 20, 377 (2001). - PMC - PubMed
    1. Wang F et al., Biochemistry 46, 7045 (2007). - PubMed
    1. Deleault NR, HarrEis BT, Rees JR, Supattapone S, Proc. Natl. Acad. Sci. U.S.A. 104, 9741 (2007). - PMC - PubMed
    1. Geoghegan JC et al., J. Biol. Chem. 282, 36341 (2007). - PMC - PubMed
    1. Wang F, Wang X, Yuan C-G, Ma J, Science 327, 1132 (2010); published online 28 January 2010. (10.1126/science.1183748). - DOI - PMC - PubMed

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