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. 2010 Apr;63(4):183-6.
doi: 10.1038/ja.2010.14. Epub 2010 Feb 26.

Calpinactam, a new anti-mycobacterial agent, produced by Mortierella alpina FKI-4905

Nobuhiro Koyama  1 , Shigenobu Kojima, Kenichi Nonaka, Rokuro Masuma, Makoto Matsumoto, Satoshi Omura, Hiroshi Tomoda
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Calpinactam, a new anti-mycobacterial agent, produced by Mortierella alpina FKI-4905

Nobuhiro Koyama et al. J Antibiot (Tokyo). 2010 Apr.

Abstract

Calpinactam, a new anti-mycobacterial agent, was isolated from the culture broth of a fungal strain Mortierella alpina FKI-4905 by solvent extraction, octadecyl silane column chromatography and preparative HPLC. Calpinactam was active only against Mycobacteria among various microorganisms, including Gram-positive and Gram-negative bacteria, fungi and yeasts. Calpinactam inhibited the growth of Mycobacterium smegmatis and Mycobacterium tuberculosis with MIC values of 0.78 and 12.5 microg ml(-1), respectively.

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