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. 2010 Feb 18:4:73-6.
doi: 10.2147/opth.s8599.

Fibrinogen and rhegmatogenous retinal detachment: a pilot prospective study

Ip Theocharis  1
Affiliations

Fibrinogen and rhegmatogenous retinal detachment: a pilot prospective study

Ip Theocharis. Clin Ophthalmol. .

Abstract

Purpose: To examine the correlation, if any, between fibrinogen plasma levels (FPL) and the clinical features of rhegmatogenous retinal detachment (RRD).

Methods: FPL were measured preoperatively in 33 patients with primary RRD. Patient characteristics and detachment features such as the numbers of breaks and the extent of the detachment were recorded;

Results: No statistically significant correlation was found between FPL and the number of breaks. A statistically significant correlation was found between FPL and the extent of the RRD, even if the influence of the number of breaks was excluded.

Conclusions: FPL correlate with retinal detachment extent, which implicates an acute inflammatory response to detachment traumatic phenomenon or a role of the fibrinogen molecule in retinal adhesiveness.

Keywords: fibrinogen; pathogenesis; retinal detachment.

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Figures

Figure 1
Figure 1
Fibrinogen and extension of the detachment (scatter plot). Notes: Each point represents one retinal detachment case. Abbreviation: FPL, fibrinogen plasma levels.
See this image and copyright information in PMC

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References

    1. Kannen WB. Influence of fibrinogen on cardiovascular disease. Framingham Heart study. Drugs. 1997;54(Suppl 3):32–40. - PubMed
    1. Risk factors for idiopathic macular holes. The Eye Disease Case-Control Study Group. Am J Ophthalmol. 1994;118(6):754–761. - PubMed
    1. Sjolie AK, Stephenson J, Aldington S, et al. Retinopathy and vision loss in insulin-dependent diabetes in Europe. The EURODIAB IDDM Complications Study. Ophthalmology. 1997;104(2):252–260. - PubMed
    1. Smith W, Mitchell P, Leeder SR, Wang JJ. Plasma fibrinogen levels, other cardiovascular risk factors, and age related maculopathy: the Blue Mountains Eye Study. Arch Ophthalmol. 1998;116(5):583–587. - PubMed
    1. Theoharis IP, Mangouritsas G, Feretis E. Fibrinogen and detached retina with or without proliferation. Acta Ophthalmol Scand. 2000;78(6):660–662. - PubMed

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