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Case Reports
. 2011 May;21(5):684-5.
doi: 10.1007/s11695-010-0107-1.

Reduced phenytoin levels in an epileptic patient following Roux-En-Y gastric bypass for obesity

Dimitrios J Pournaras  1 , David Footitt, David Mahon, Richard Welbourn
Affiliations
Case Reports

Reduced phenytoin levels in an epileptic patient following Roux-En-Y gastric bypass for obesity

Dimitrios J Pournaras et al. Obes Surg. 2011 May.

Abstract

Despite widespread uptake of bariatric procedures for severe obesity, changes in pharmacodynamics after surgery are poorly understood. We report an epileptic patient who had a seizure following gastric bypass, although he had been asymptomatic for 30 years and without any change in his treatment. Phenytoin levels were undetectable despite a high dose. Drugs with a narrow therapeutic range such as phenytoin should be prescribed with caution after bariatric surgery.

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References

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