[Development of hair follicle stem cells related signal transduction in proliferation and differentiation]

Abstract

Objective: To introduce the basic research and clinical potential of the hair follicle stem cells related signal transduction in proliferation and differentiation.

Methods: The recent original articles about the hair follicle stem cells were extensively reviewed.

Results: Many different signal pathways had been involved in the skin development and self-newals.The hair follicle stem cells could play an important role in the skin self-renewal and regeneration which were modulated by several different signal pathways, which included bone morphogenetic protein/transforming growth factor beta, Wnt, Notch and ectodysplasin A genes.

Conclusion: The hair follicle stem cells may be a future approach to repair cutaneous wounds as a cell therapy.