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. 2010 Apr 1;201(7):1031-4.
doi: 10.1086/651169.

Serological evidence of human hantavirus infections in Guinea, West Africa

Boris Klempa  1 , Lamine Koivogui, Oumar Sylla, Kekoura Koulemou, Brita Auste, Detlev H Krüger, Jan ter Meulen
Affiliations

Serological evidence of human hantavirus infections in Guinea, West Africa

Boris Klempa et al. J Infect Dis. .

Abstract

We recently discovered a novel hantavirus, Sangassou virus, in Guinea, West Africa. Using enzyme-linked immunosorbent assays followed by confirmatory and serotyping assays, we retrospectively detected hantavirus antibodies in 3 (4.4%) of 68 patients with fever of unknown origin in Sangassou village, Forest Guinea. A population-based survey in Forest Guinea (n = 649) found the prevalence of hantavirus antibodies to be 1.2%. Specific neutralizing antibodies against Sangassou virus were demonstrated in serum samples from 2 patients and in 2 serum samples of the serosurvey. Our data allow us to conclude that hantavirus infections may be a significant unrecognized medical problem in at least this part of Africa.

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