Fertility preservation by ovarian stimulation and oocyte cryopreservation in a 14-year-old adolescent with Turner syndrome mosaicism and impending premature ovarian failure

Abstract

Objective: To report a novel approach to fertility preservation in adolescents with Turner syndrome mosaicism by repeated controlled ovarian stimulation and oocyte cryopreservation.

Design: Case report.

Setting: Academic reproductive medicine center.

Patient(s): Fourteen-year-old adolescent diagnosed with Turner syndrome mosaicism.

Intervention(s): Two cyles of controlled ovarian stimulation and oocyte cryopreservation within 1 year.

Main outcome measure(s): Recovery of oocytes after controlled ovarian stimulation and oocyte cryopreservation.

Result(s): Eleven oocytes were retrieved, of which eight were mature and three were immature during the first cycle. One year later, four mature and three immature oocytes were retrieved after a treatment cycle with even higher gonadotropin doses. All oocytes were cryopreserved by vitrification.

Conclusion(s): Controlled ovarian stimulation and oocyte cryopreservation may be an option for fertility preservation in selected adolescents with Turner syndrome mosaicism and impending ovarian failure.