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Comparative Study
. 2010 Jul;121(7):1080-4.
doi: 10.1016/j.clinph.2009.10.038. Epub 2010 Feb 25.

Retinal origin of phosphenes to transcranial alternating current stimulation

Dennis J L G Schutter  1 , Ruud Hortensius
Affiliations
Comparative Study

Retinal origin of phosphenes to transcranial alternating current stimulation

Dennis J L G Schutter et al. Clin Neurophysiol. 2010 Jul.

Abstract

Objective: To examine possible retinal contributions to cortically induced phosphenes by transcranial alternating current stimulation (tACS) involving the visual cortex.

Methods: Self-reported phosphene ratings and voltage-related potentials from the canthus, supra-orbital and sub-orbital regions of the right eye were measured to 2, 10 and 20 Hz tACS at 250 and 1000 microA intensities in healthy volunteers.

Results: Qualitatively similar, but more intense phosphenes were reported during frontalis-vertex tACS as compared to occiput-vertex tACS. In addition, voltage-related potentials were recorded at the canthus and orbit regions of the eye during frontalis-vertex, occiput-vertex and occiput-right shoulder tACS.

Conclusions: The experience of phosphenes during tACS involving the visual cortex is influenced by volume conductions effects of the scalp.

Significance: Retinal effects should be taken into account when studying the cortical modulatory effects of tACS.

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