Now you see it, now you don't--closing in on allostasis and developmental basis of psychiatric disorders
- PMID: 20188647
- DOI: 10.1016/j.neuron.2010.02.010
Now you see it, now you don't--closing in on allostasis and developmental basis of psychiatric disorders
Abstract
The mode through which early insults in brain development result in the onset of psychiatric disorders years after impact become a little less mysterious with the report by Niwa et al. that a transient reduction of the schizophrenia risk gene DISC1 can alter prefrontal cortex neurochemistry, architecture, and function.
Comment on
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Knockdown of DISC1 by in utero gene transfer disturbs postnatal dopaminergic maturation in the frontal cortex and leads to adult behavioral deficits.Neuron. 2010 Feb 25;65(4):480-9. doi: 10.1016/j.neuron.2010.01.019. Neuron. 2010. PMID: 20188653 Free PMC article.
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