Comment
doi: 10.1016/j.molcel.2010.02.005.
Taking MLL through the MudPIT: identification of novel complexes that bring together MLL-fusion proteins and transcription elongation factors
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- PMID: 20188661
- DOI: 10.1016/j.molcel.2010.02.005
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Comment
Taking MLL through the MudPIT: identification of novel complexes that bring together MLL-fusion proteins and transcription elongation factors
Mol Cell.
.
Free article
Abstract
Recently in Molecular Cell, Lin et al. (2010) showed that multiple MLL-fusion proteins implicated in mixed-lineage leukemia (MLL) associate with AFF4, ELLs, and the positive transcription elongation factor P-TEFb, providing evidence that the dysregulated gene expression in MLL patients is due to aberrant transcription elongation.
Copyright 2010 Elsevier Inc. All rights reserved.
Comment on
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AFF4, a component of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia.Mol Cell. 2010 Feb 12;37(3):429-37. doi: 10.1016/j.molcel.2010.01.026. Mol Cell. 2010. PMID: 20159561 Free PMC article.
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