For T cell receptors, some breakups might not last forever
- PMID: 20189475
- DOI: 10.1016/j.immuni.2010.02.005
For T cell receptors, some breakups might not last forever
Abstract
Does the affinity or half-life of peptide-MHC-T cell receptor (TCR) interactions determine T cell activation? In this issue of Immunity, Aleksic et al. (2010) propose a role for the on rate through multiple rebindings to the same TCR.
Copyright 2010 Elsevier Inc. All rights reserved.
Comment on
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Dependence of T cell antigen recognition on T cell receptor-peptide MHC confinement time.Immunity. 2010 Feb 26;32(2):163-74. doi: 10.1016/j.immuni.2009.11.013. Epub 2010 Feb 4. Immunity. 2010. PMID: 20137987 Free PMC article.
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