Immobile BCRs: the safety on the signal trigger
- PMID: 20189476
- DOI: 10.1016/j.immuni.2010.02.007
Immobile BCRs: the safety on the signal trigger
Abstract
B cell receptor (BCR)-mediated tonic signals are important for B cell survival and development. In this issue of Immunity, Treanor et al. (2010) show that triggering of downstream responses is kept in check with BCR immobilization by actin.
Copyright 2010 Elsevier Inc. All rights reserved.
Comment on
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The membrane skeleton controls diffusion dynamics and signaling through the B cell receptor.Immunity. 2010 Feb 26;32(2):187-99. doi: 10.1016/j.immuni.2009.12.005. Epub 2010 Feb 18. Immunity. 2010. PMID: 20171124 Free PMC article.
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