Temperature effects on the modulation of adenylate cyclases from rat liver and Morris hepatomas

Abstract

When adenylate cyclase activities in purified membranes from normal rat liver and from a series of rapid growing transplantable Morris hepatomas were examined at various temperatures, several unique features were observed. Two of the hepatomas yielded patterns similar to that of normal liver, even though glucagon did not activate either tumor adenylate cyclase but did activate the normal liver enzyme. The patterns of the third tumor line were completely different from normal. This clearly shows the heterogeneity in cancers of similar origin.