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Case Reports
. 2010;49(5):487-90.
doi: 10.2169/internalmedicine.49.2746. Epub 2010 Mar 1.

Type B insulin resistance complicated with systemic lupus erythematosus

Shin-Ya Kawashiri  1 , Atsushi Kawakami, Keita Fujikawa, Naoki Iwamoto, Toshiyuki Aramaki, Mami Tamai, Hideki Nakamura, Tomoki Origuchi, Hiroaki Ida, Katsumi Eguchi
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Free article
Case Reports

Type B insulin resistance complicated with systemic lupus erythematosus

Shin-Ya Kawashiri et al. Intern Med. 2010.
Free article

Abstract

Type B insulin resistance is characterized by the appearance of autoantibodies to the insulin receptor. We present a 59-year-old Japanese man with type B insulin resistance complicated with systemic lupus erythematosus (SLE). A high titer of anti-insulin receptor autoantibodies was revealed when SLE was defined as active disease. Intravenous boluses of cyclophosphamide (IVCY) with oral prednisolone and cyclosporin A induced remission of SLE, and a subsequent disappearance of anti-insulin receptor autoantibodies, followed by a recovery of glucose intolerance. This is a rare and important case report showing a clear correlation between anti-insulin receptor autoantibodies of type B insulin resistance and SLE disease activity.

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