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Comment
. 2010 Mar;12(3):207-9.
doi: 10.1038/ncb0310-207.

p62, an autophagy hero or culprit?

Tor Erik Rusten  1 , Harald Stenmark
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p62, an autophagy hero or culprit?

Tor Erik Rusten et al. Nat Cell Biol. 2010 Mar.

Abstract

The p62 protein recognizes toxic cellular waste, which is then scavenged by a sequestration process known as self-eating or autophagy. Lack of autophagy leads to accumulation of p62, which is not good for liver cells, as it induces a cellular stress response that leads to disease.

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