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Randomized Controlled Trial
. 2009 Dec;50(12):1257-62.

Efficacy of a 5-day extended therapy program during lactation with cephapirin sodium in dairy cows chronically infected with Staphylococcus aureus

Jean-Philippe Roy  1 , Luc DesCôteaux, Denis DuTremblay, Francis Beaudry, Johanne Elsener
Affiliations
Randomized Controlled Trial

Efficacy of a 5-day extended therapy program during lactation with cephapirin sodium in dairy cows chronically infected with Staphylococcus aureus

Jean-Philippe Roy et al. Can Vet J. 2009 Dec.

Abstract
in English, French

This study determined the efficacy of a 5-day extended therapy with cephapirin sodium in dairy cows chronically infected with Staphylococcus aureus. Chronically infected cows selected from 14 dairy herds in the St-Hyacinthe region, Québec were randomly allocated to a group of 31 cows treated for 5 consecutive days with 200 mg of cephapirin per quarter BID or a group of 30 untreated control cows. Bacteriological cure was determined by 3 negative bacterial cultures at 10, 24, and 31 days after treatment. The cow cure rates were 25.8% (8/31) in the treated cows and 3.3% (1/30) in the control group (P = 0.013). The quarter cure rates at first sampling post-treatment were 77.6% (38/49) and 18% (9/50) in the treated and the control groups, respectively (P < 0.0001). A 5-day extended therapy with cephapirin is effective in treating cows chronically infected with S. aureus.

Efficacité d’un programme de thérapie prolongée de 5 jours à la céphapirine sodique durant la lactation chez les vaches laitières chroniquement infectées par Staphylococcus aureus. L’étude a déterminé l’efficacité d’une thérapie prolongée de 5 jours à la céphapirine sodique chez des vaches laitières chroniquement infectées par Staphylococcus aureus. Les vaches chroniquement infectées choisies de 14 troupeaux laitiers dans la région de Saint-Hyachinthe, au Québec, ont été assignées au hasard à un groupe de 31 vaches traitées pendant 5 jours consécutifs avec 200 mg de céphapirine par quartier bid ou à un groupe témoin de 30 vaches non traitées. La guérison bactériologique a été déterminée par 3 cultures bactériennes négatives 10, 24 et 31 jours après le traitement. Les taux de guérison des vaches étaient de 25,8 % (8/31) chez les vaches traitées et de 3,3 % (1/30) dans le groupe témoin (P = 0,013). Les taux de guérison des quartiers au premier échantillon après le traitement étaient de 77,6 % (38/49) et de 18 % (9/50) dans le groupe traité et le groupe témoin, respectivement (P < 0,0001). Une thérapie prolongée de 5 jours à la céphapirine est efficace pour traiter les vaches chroniquement infectées par S. aureus.

(Traduit par Isabelle Vallières)

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