Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2009 Dec;50(12):1257-62.

Efficacy of a 5-day extended therapy program during lactation with cephapirin sodium in dairy cows chronically infected with Staphylococcus aureus

Jean-Philippe Roy  1 , Luc DesCôteaux, Denis DuTremblay, Francis Beaudry, Johanne Elsener
Affiliations
Randomized Controlled Trial

Efficacy of a 5-day extended therapy program during lactation with cephapirin sodium in dairy cows chronically infected with Staphylococcus aureus

Jean-Philippe Roy et al. Can Vet J. 2009 Dec.

Abstract
in English, French

This study determined the efficacy of a 5-day extended therapy with cephapirin sodium in dairy cows chronically infected with Staphylococcus aureus. Chronically infected cows selected from 14 dairy herds in the St-Hyacinthe region, Québec were randomly allocated to a group of 31 cows treated for 5 consecutive days with 200 mg of cephapirin per quarter BID or a group of 30 untreated control cows. Bacteriological cure was determined by 3 negative bacterial cultures at 10, 24, and 31 days after treatment. The cow cure rates were 25.8% (8/31) in the treated cows and 3.3% (1/30) in the control group (P = 0.013). The quarter cure rates at first sampling post-treatment were 77.6% (38/49) and 18% (9/50) in the treated and the control groups, respectively (P < 0.0001). A 5-day extended therapy with cephapirin is effective in treating cows chronically infected with S. aureus.

Efficacité d’un programme de thérapie prolongée de 5 jours à la céphapirine sodique durant la lactation chez les vaches laitières chroniquement infectées par Staphylococcus aureus. L’étude a déterminé l’efficacité d’une thérapie prolongée de 5 jours à la céphapirine sodique chez des vaches laitières chroniquement infectées par Staphylococcus aureus. Les vaches chroniquement infectées choisies de 14 troupeaux laitiers dans la région de Saint-Hyachinthe, au Québec, ont été assignées au hasard à un groupe de 31 vaches traitées pendant 5 jours consécutifs avec 200 mg de céphapirine par quartier bid ou à un groupe témoin de 30 vaches non traitées. La guérison bactériologique a été déterminée par 3 cultures bactériennes négatives 10, 24 et 31 jours après le traitement. Les taux de guérison des vaches étaient de 25,8 % (8/31) chez les vaches traitées et de 3,3 % (1/30) dans le groupe témoin (P = 0,013). Les taux de guérison des quartiers au premier échantillon après le traitement étaient de 77,6 % (38/49) et de 18 % (9/50) dans le groupe traité et le groupe témoin, respectivement (P < 0,0001). Une thérapie prolongée de 5 jours à la céphapirine est efficace pour traiter les vaches chroniquement infectées par S. aureus.

(Traduit par Isabelle Vallières)

PubMed Disclaimer

References

    1. Bradley AJ, Leach KA, Breen JE, Green MJ. Survey of the incidence and aetiology of mastitis on dairy farms in England and Wales. Vet Rec. 2007;160:253–258. - PubMed
    1. Olde Riekerink RGM, Barkema HW, Kelton DF, Scholl DT. Incidence rate of clinical mastitis on Canadian dairy farms. J Dairy Sci. 2008;91:1366–1377. - PubMed
    1. Barkema HW, Schukken YH, Zadoks RN. Invited review: The role of cow, pathogen, and treatment regimen in the therapeutic success of bovine Staphylococcus aureus mastitis. J Dairy Sci. 2006;89:1877–1895. - PubMed
    1. Shpigel NY, Kass PH, Saran A. A comparative randomized field trial on intramammary and intramuscular dry cow antibiotic treatment of subclinical Staphylococcus aureus mastitis in dairy cows. J Vet Med A. 2006;53:418–422. - PubMed
    1. Seegers H, Fourichon C, Beaudeau F. Production effects related to mastitis and mastitis economics in dairy cattle herds. Vet Res. 2003;34:475–491. - PubMed

Publication types

LinkOut - more resources