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. 2010 Mar;51(2):244-7.
doi: 10.3349/ymj.2010.51.2.244. Epub 2010 Feb 12.

Urolithiasis in patients suffering from malignant hematologic diseases

Sae Woong Kim  1 , Sung Dae Kim, Je Mo Yoo, Yong-Hyun Cho, Dong Wan Sohn
Affiliations

Urolithiasis in patients suffering from malignant hematologic diseases

Sae Woong Kim et al. Yonsei Med J. 2010 Mar.

Abstract

Purpose: We performed this study in order to evaluate the incidence and characteristics of urolithiasis in patients with malignant hematologic diseases.

Materials and methods: Nine hundred one patients who underwent medical treatment for malignant hematologic disease and 40,543 patients who visited the emergency room and without malignant hematologic diseases were included in our study. The patients with malignant hematologic diseases were divided into two groups depending on their primary treatment. Group I included patients with acute and chronic leukemia (AML, ALL, CML, CLL) for which chemotherapy and steroid therapy was necessary, and group II included patients with anaplastic anemia and myelodysplastic syndrome and who had undergone repeated transfusion for treatment. Comparisons were made between the two groups in respect to the incidence of urolithiasis and the stones' radiopacity.

Results: Twenty nine patients (3.2%) of the 901 malignant hematologic patients were diagnosed with urolithiasis, compared to 575 patients (1.4%) of 40,543 emergency room patients. There was a significant increase of the incidence of urolithiasis in the malignant hematologic group. Compared to the general patients, the patients with malignant hematologic diseases had a higher rate of radiolucent stones (46.6% versus 16.3%, respectively), and the difference was significant.

Conclusion: The incidence of urolithiasis for malignant hematologic patients was significantly higher than that for the control group.

Keywords: Malignant hematologic disease; incidence; urolithiasis.

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Conflict of interest statement

The authors have no financial conflicts of interest.

Figures

Fig. 1
Fig. 1
Comparison of the stone incidence in the study group and the control group. Study group: patients of malignant hematologic disease, Control group: patients who visited the emergency room (p = 0.04).
Fig. 2
Fig. 2
Comparison of the incidence of radiolucent stones between control and study group. Study group: patients of malignant hematologic disease. Control group: patients who visited the emergency room (p = 0.02).
See this image and copyright information in PMC

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