Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2011 Feb;15(1):3-33.
doi: 10.1007/s11030-010-9229-6. Epub 2010 Feb 27.

The Gewald multicomponent reaction

Yijun Huang  1 , Alexander Dömling
Affiliations
Review

The Gewald multicomponent reaction

Yijun Huang et al. Mol Divers. 2011 Feb.

Abstract

The Gewald reaction of sulfur, cyanoacetic acid derivatives, and oxo-component (G-3CR) yielding highly substituted 2-aminothiophene derivatives has seen diverse applications in combinatorial and medicinal chemistry. Its products are of great use in pharmaceutical industry mainly as small molecular weight inhibitors. We herein review synthetic scope and variations, usage, and structural biology of Gewald products.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. J Biol Chem. 2000 Jun 16;275(24):18201-9 - PubMed
    1. Drug Discov Today. 2007 May;12(9-10):373-81 - PubMed
    1. Bioorg Med Chem. 2002 Oct;10(10):3113-22 - PubMed
    1. Arch Pharm Res. 2001 Aug;24(4):270-5 - PubMed
    1. J Comb Chem. 2008 Nov-Dec;10(6):863-8 - PubMed

Publication types

LinkOut - more resources