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. 2010 Jun;26(5):487-97.
doi: 10.1007/s10554-010-9599-y. Epub 2010 Feb 27.

Impact of analyzing less image frames per segment for radiofrequency-based volumetric intravascular ultrasound measurements in mild-to-moderate coronary atherosclerosis

Jennifer Huisman  1 , Marc Hartmann, Eline S K Mattern, Gary S Mintz, Mounir W Z Basalus, Gert K van Houwelingen, Patrick M J Verhorst, Clemens von Birgelen
Affiliations

Impact of analyzing less image frames per segment for radiofrequency-based volumetric intravascular ultrasound measurements in mild-to-moderate coronary atherosclerosis

Jennifer Huisman et al. Int J Cardiovasc Imaging. 2010 Jun.

Abstract

Volumetric radiofrequency-based intravascular ultrasound (RF-IVUS) data of coronary segments are increasingly used as endpoints in serial trials of novel anti-atherosclerotic therapies. In a relatively time-consuming process, vessel and lumen contours are defined; these contours are first automatically detected, then visually checked, and finally (in most cases) manually edited to generate reliable volumetric data of vessel geometry and plaque composition. Reduction in number of cross-sectional images for volumetric analysis could save analysis time but may also increase measurement variability of volumetric data. To assess whether a 50% reduction in number of frames per segment (every second frame) alters the reproducibility of volumetric measurements, we performed repeated RF-IVUS analyses of 15 coronary segments with mild-to-moderate atherosclerosis (20.2 +/- 0.2 mm-long segments with 46 +/- 13% plaque burden). Volumes were calculated based on a total of 731 image frames. Reducing the number of cross-sectional image frames for volumetric measurements saved analysis time (38 +/- 9 vs. 68 +/- 17 min/segment; P < 0.0001) and resulted for only a few parameters in (borderline) significant but mild differences versus measurements based on all frames (fibrous volume, P < 0.05; necrotic-core volume, P = 0.07). Compared to the intra-observer variability, there was a mild increase in measurement variability for most geometrical and compositional volumetric RF-IVUS parameters. In RF-IVUS studies of mild-to-moderate coronary disease, analyzing less image frames saved analysis time, left most volumetric parameters greatly unaffected, and resulted in a no more than mild increase in measurement variability of volumetric data.

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Figures

Fig. 1
Fig. 1
Different ways of RF-data analysis and generation of volumetric data
Fig. 2
Fig. 2
Bland–Altman comparison of different ways of RF-IVUS analysis for geometrical data
Fig. 3
Fig. 3
Bland–Altman comparison of different ways of RF-IVUS analysis for compositional data
See this image and copyright information in PMC

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