Gene discovery in rheumatoid arthritis highlights the CD40/NF-kappaB signaling pathway in disease pathogenesis
- PMID: 20192992
- DOI: 10.1111/j.0105-2896.2009.00862.x
Gene discovery in rheumatoid arthritis highlights the CD40/NF-kappaB signaling pathway in disease pathogenesis
Abstract
During the past several years, substantial progress has been made in the identification of genetic variants that predispose to rheumatoid arthritis (RA) and other autoimmune disorders. Progress in this area has been facilitated by the availability of new technology that allows for a much more comprehensive screen of the genome than was possible before, in conjunction with large samples of RA patients with well-characterized disease. Recent RA genetic studies have identified genes with important functions related to intracellular signaling mechanisms, transcription factors, cytokines, membrane receptors, costimulatory molecules, and enzymes. In particular, recent discoveries highlight the importance of the CD40/NF-kappaB signaling pathway in RA, based on genetic association with several genes relevant to this pathway, including CD40, TRAF1, TNFAIP3, and REL. Progress in the identification of genes that contribute to RA is proceeding at a very rapid pace. These genetic discoveries shed light on underlying disease mechanisms in RA and provide targets for the development of novel diagnostic and therapeutic tools for future use in this chronic inflammatory disorder.
Similar articles
-
Recent progress in rheumatoid arthritis genetics: one step towards improved patient care.Curr Opin Rheumatol. 2009 May;21(3):262-71. doi: 10.1097/BOR.0b013e32832a2e2d. Curr Opin Rheumatol. 2009. PMID: 19365266 Review.
-
Unraveling the genetics of complex diseases: susceptibility genes for rheumatoid arthritis and psoriasis.Semin Immunol. 2009 Dec;21(6):318-27. doi: 10.1016/j.smim.2009.04.002. Epub 2009 May 14. Semin Immunol. 2009. PMID: 19446472 Review.
-
Rheumatoid arthritis: a disease of chronic, low-amplitude signals transduced through T cell antigen receptors?Wien Med Wochenschr. 2006 Jan;156(1-2):2-10. doi: 10.1007/s10354-005-0246-5. Wien Med Wochenschr. 2006. PMID: 16465609 Review.
-
Genetics in neuroendocrine immunology: implications for rheumatoid arthritis and osteoarthritis.Ann N Y Acad Sci. 2010 Apr;1193:10-4. doi: 10.1111/j.1749-6632.2009.05288.x. Ann N Y Acad Sci. 2010. PMID: 20398001 Review.
-
Signalling, inflammation and arthritis: NF-kappaB and its relevance to arthritis and inflammation.Rheumatology (Oxford). 2008 May;47(5):584-90. doi: 10.1093/rheumatology/kem298. Epub 2008 Jan 29. Rheumatology (Oxford). 2008. PMID: 18234712 Review.
Cited by
-
Gene network analysis of small molecules with autoimmune disease associated genes predicts a novel strategy for drug efficacy.Autoimmun Rev. 2013 Feb;12(4):510-22. doi: 10.1016/j.autrev.2012.09.001. Epub 2012 Sep 18. Autoimmun Rev. 2013. PMID: 23000205 Free PMC article.
-
Peptide-siRNA nanocomplexes targeting NF-κB subunit p65 suppress nascent experimental arthritis.J Clin Invest. 2014 Oct;124(10):4363-74. doi: 10.1172/JCI75673. Epub 2014 Aug 26. J Clin Invest. 2014. PMID: 25157820 Free PMC article.
-
Dysregulation of Toll-Like Receptor Signaling-Associated Gene Expression in X-Linked Agammaglobulinemia: Implications for Correlations Genotype-Phenotype and Disease Expression.J Innate Immun. 2024;16(1):425-439. doi: 10.1159/000540082. Epub 2024 Aug 8. J Innate Immun. 2024. PMID: 39116841 Free PMC article.
-
Transcriptional Factor NF-κB as a Target for Therapy in Parkinson's Disease.Parkinsons Dis. 2011;2011:216298. doi: 10.4061/2011/216298. Epub 2011 Mar 30. Parkinsons Dis. 2011. PMID: 21603248 Free PMC article.
-
CD40 in coronary artery disease: a matter of macrophages?Basic Res Cardiol. 2016 Jul;111(4):38. doi: 10.1007/s00395-016-0554-5. Epub 2016 May 4. Basic Res Cardiol. 2016. PMID: 27146510 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials
Miscellaneous