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Review
. 1977 Oct;53(624):588-91.
doi: 10.1136/pgmj.53.624.588.

Cytomegalovirus infection in the neonate and its prevention

H Stern
Review

Cytomegalovirus infection in the neonate and its prevention

H Stern. Postgrad Med J. 1977 Oct.

Abstract

About 0.5% of infants are infected in utero with cytomegalovirus (CMV). As many as 20% become mentally retarded and a further substantial proportion suffer lesser degrees of brain damage. The need for a vaccine is greater than in the case of rubella. A live, tissue culture-adapted strain of CMV has been shown to produce neutralizing antibody in volunteers without significant side effects or detectable virus excretion. The problems of developing such a vaccine for use in man, namely, attenuation, antigenic differences among virus strains, reactivation of latent infection and oncogenicity, are briefly discussed.

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