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Editorial
. 2010 Apr;55(4):846-8.
doi: 10.1161/HYPERTENSIONAHA.109.148346. Epub 2010 Mar 1.

EP1c times for angiotensin: EP1 receptors facilitate angiotensin II-induced vascular dysfunction

Ricardo A Pena-Silva, Donald D Heistad
Editorial

EP1c times for angiotensin: EP1 receptors facilitate angiotensin II-induced vascular dysfunction

Ricardo A Pena-Silva et al. Hypertension. 2010 Apr.
No abstract available

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Conflict of interest statement

Disclosures: No relevant conflict of interest.

Figures

Figure 1
Figure 1
Prostaglandin E2 (PGE2) is a product of metabolism of arachidonic acid (AA) by cyclooxygenase I (COX-1) and the prostaglandin E synthase (PGES), perhaps in microglia. Activation of prostaglandin EP1 receptors by PGE2 on cerebral blood vessels, may increase the intracellular concentrations of calcium (Ca++) or facilitate the activation of regulatory kinases by angiotensin II (Ang II) type I (AT1) receptors, which are required for activation of the NAD(P)H oxidase. Reactive oxygen species (ROS) derived from the active NAD(P)H oxidase, are associated with increased arterial pressure, endothelial dysfunction, and impaired neurovascular coupling.
See this image and copyright information in PMC

Comment on

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