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. 2010 May;54(5):2244-7.
doi: 10.1128/AAC.01527-09. Epub 2010 Mar 1.

Synergistic activities of three triazoles with caspofungin against Candida glabrata isolates determined by time-kill, Etest, and disk diffusion methods

Nuri Kiraz  1 , Ilknur Dag, Mustafa Yamac, Abdurrahman Kiremitci, Nilgun Kasifoglu, Yasemin Oz
Affiliations

Synergistic activities of three triazoles with caspofungin against Candida glabrata isolates determined by time-kill, Etest, and disk diffusion methods

Nuri Kiraz et al. Antimicrob Agents Chemother. 2010 May.

Abstract

Combinations of voriconazole, fluconazole, and itraconazole with caspofungin were evaluated against 50 Candida glabrata isolates by the time-kill, disk diffusion, and Etest methods. The majority of antifungal combinations were indifferent. By the time-kill method, synergistic activity was detected with eight (16%) of the caspofungin-voriconazole and seven (14%) of the caspofungin-fluconazole combinations, but synergy was not seen with the caspofungin-itraconazole combination. Further comparisons of the Etest and disk diffusion synergy techniques with the time-kill method are warranted.

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Figures

FIG. 1.
FIG. 1.
Representation by the Etest synergy method of caspofungin (CS) in combination with voriconazole (VO) (a), itraconazole (IT) (b), or fluconazole (FL) (c) (strains 4, 6, and 20).
FIG. 2.
FIG. 2.
Results obtained with antifungal combinations by the time-kill (a) and Etest (b) methods.
See this image and copyright information in PMC

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