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. 2010 Feb 26;6(2):e1000861.
doi: 10.1371/journal.pgen.1000861.

Nucleoporins and transcription: new connections, new questions

Kohta Ikegami  1 , Jason D Lieb
Affiliations

Nucleoporins and transcription: new connections, new questions

Kohta Ikegami et al. PLoS Genet. .
No abstract available

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Nucleoporins Nup153 and Mtor are located at both NPCs and the nuclear interior, and associate with active transcription.
(A) Schematic representation of Nup153 (left) – and Mtor (right) ,, localization at the NPC and the nucleoplasm. Nup153 is proposed to be localized at the nuclear coaxial ring in proximity to the nuclear membrane (1); at the distal pore basket (2); as nucleoplasmic filaments (3); and shuttle between NPCs and the nucleoplasmic pool (arrow, 4). Mtor is proposed to constitute the pore basket (5) and nucleoplasmic filaments or granules (6). The mobile property of Mtor is unknown (7). It is still unclear whether the nucleoplasmic NUP153 and Mtor structures are extended from NPCs (dotted ovals). (B) Possible role of nucleoplasmic nucleoporins in transporting mRNA from the nuclear interior to NPCs.
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