Copper-mediated N-heteroarylation of primary sulfonamides: synthesis of mono-N-heteroaryl sulfonamides

Abstract

We describe the coupling of primary sulfonamides and various halogenated heterocyclic cores, with an emphasis on 2-heteroaryl halides, via copper catalysis. These studies enabled the synthesis of many new mono-N-heteroaryl sulfonamides. The electronic factors that influence the course of the reaction have also been investigated.