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. 2010;9(1):Article 1.
doi: 10.2202/1544-6115.1517. Epub 2010 Jan 6.

Epistatic interactions

Tyler J VanderWeele  1
Affiliations

Epistatic interactions

Tyler J VanderWeele. Stat Appl Genet Mol Biol. 2010.

Abstract

The term "epistasis" is sometimes used to describe some form of statistical interaction between genetic factors and is alternatively sometimes used to describe instances in which the effect of a particular genetic variant is masked by a variant at another locus. In general statistical tests for interaction are of limited use in detecting "epistasis" in the sense of masking. It is, however, shown that there are relations between empirical data patterns and epistasis that have not been previously noted. These relations can sometimes be exploited to empirically test for "epistatic interactions" in the sense of the masking of the effect of a particular genetic variant by a variant at another locus.

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References

    1. Bateson W. Mendel’s Principles of Heredity. Cambridge University Press; Cambridge: 1909.
    1. Chung Y, Lee SY, Elston RC, Park T. Odds ratio based multifactor-dimensionality reduction method for detecting gene–gene interactions. Bioinformatics. 2007;23:71–76. doi: 10.1093/bioinformatics/btl557. - DOI - PubMed
    1. Cordell HJ. Epistasis: what it means, what it doesn’t mean, and statistical methods to detect it in humans. Hum Mol Genet. 2002;11:2463–2468. doi: 10.1093/hmg/11.20.2463. - DOI - PubMed
    1. Cordell HJ. Detecting gene-gene interaction that underlie human diseases. Nat Rev Genet. 2009;10:392–404. doi: 10.1038/nrg2579. - DOI - PMC - PubMed
    1. Cordell HJ, Clayton DG. A unified stepwise regression procedure for evaluating the relative effects of polymorphisms within a gene using case/control or family data: application to HLA in type 1 diabetes. Am J Hum Genet. 2002;70:124–141. doi: 10.1086/338007. - DOI - PMC - PubMed

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